<h1><span style="color: #000000;"><strong>POSITION SUMMARY</strong></span></h1> <p><span style="color: #000000;">Natera is seeking a highly motivated Scientist, R&D – Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the development, optimization, verification, and validation of IHC and tissue-based workflows supporting oncology products and clinical assay development.</span></p> <p><span style="color: #000000;">The ideal candidate will have strong hands-on experience in IHC assay development and optimization, supported by a solid foundation in histology and FFPE tissue workflows. Experience with automated IHC/ISH staining platforms, particularly the Roche BenchMark ULTRA IHC/ISH System, is highly desirable. Experience with NGS and molecular biology workflows is an additional plus.</span></p> <h1><span style="color: #000000;"><strong>PRIMARY RESPONSIBILITIES</strong></span></h1> <ul> <li style="color: #000000 !important;"><span style="color: #000000;">Design and execute development, optimization, verification, and validation studies for IHC, histology, and tissue-based workflows.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Develop and optimize IHC assays, including antibody selection and titration, antigen retrieval, staining conditions, controls, and assay performance assessment.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Evaluate and optimize histology and pre-analytical variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and slide preparation.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Develop and troubleshoot workflows on automated IHC/ISH staining platforms and investigate staining artifacts, reagent performance, tissue quality, and assay variability.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Plan and execute moderate- to high-complexity experiments; analyze and interpret results using tools such as Excel, JMP, and image-analysis approaches.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Collaborate with Pathology, Clinical Laboratory Operations, Quality, Automation, and other cross-functional teams to transfer R&D methods into robust clinical laboratory workflows.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Author study protocols, development/validation reports, SOPs, and transfer documentation, and provide technical guidance and training during implementation.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Communicate project progress, experimental findings, risks, and recommendations to project teams and stakeholders.</span></li> </ul> <p> </p> <h1><span style="color: #000000;"><strong>QUALIFICATIONS</strong></span></h1> <p><span style="color: #000000;">Ph.D. in Pathology, Cancer Biology, Molecular Biology, Cell Biology, Biomedical Sciences, or a related field with a minimum of 2 years of relevant industry experience; or a Master's degree with a minimum of 5 years of relevant industry experience; or a Bachelor's degree with a 6-8+ years of relevant industry experience.</span></p> <p> </p> <h1><span style="color: #000000;"><strong>KNOWLEDGE, SKILLS, AND ABILITIES</strong></span></h1> <ul> <li style="color: #000000 !important;"><span style="color: #000000;">Strong hands-on expertise in IHC assay development, optimization, and troubleshooting, with solid knowledge of histology and FFPE tissue workflows.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Experience with antibody characterization/titration, antigen retrieval, staining optimization, controls, tissue morphology, and assay performance evaluation.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Experience with automated IHC/ISH platforms is highly preferred; hands-on experience with the Roche BenchMark ULTRA IHC/ISH System is a strong plus.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Experience with H&E staining, microtomy/tissue sectioning, microscopy, digital pathology, or image analysis is desirable.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">NGS and molecular biology experience is a plus, particularly with FFPE nucleic acid extraction, PCR/qPCR, NGS library preparation, or hybrid capture workflows.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Experience with assay development and validation in a regulated clinical laboratory, molecular diagnostics, or LDT environment is preferred.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Ability to independently design and execute experiments, interpret data, troubleshoot technical challenges, and determine appropriate next steps.</span></li> <li style="color: #000000 !important;"><span style="color: #000000;">Strong technical writing, communication, collaboration, and organizational skills, with the ability to manage multiple priorities in a fast-paced R&D environment.</span></li> </ul><div class="content-pay-transparency"><div class="pay-input"&