<div class="content-intro"><p>Spyre Therapeutics is a clinical-stage biotechnology company committed to developing next-generation therapies that elevate the standard in immunology by delivering more complete disease control, greater durability, and a simpler treatment experience for patients. Spyre's pipeline includes investigational extended half-life antibodies targeting α4β7, TL1A, IL-23, and IL-17A/F as well as rational combination programs.</p></div><p><strong><span data-contrast="auto">Role Summary</span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"134245418":true,"335557856":16777215}"> </span></p> <p><span data-contrast="auto">We are seeking a highly skilled and motivated Senior Scientist, Translational Science, to join our growing team. This individual will support the execution of outsourced bioanalytical and biomarker activities for Spyre's clinical programs, with primary responsibility for pharmacokinetic, immunogenicity, and PD assays. This role will contribute to assay development, qualification, validation, sample analysis, data interpretation, and reporting across multiple analytical platforms at Contract Research Organizations (CROs). The Senior Scientist will serve as a scientific point of contact for CROs, communicate plans and progress within the translation sciences team, and help ensure that all activities are conducted in accordance with applicable regulatory requirements, company procedures, and program timelines.</span><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"335557856":16777215}"> </span></p> <p><strong><span data-contrast="auto">Key Responsibilities</span></strong><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"134245418":true,"335557856":16777215}"> </span></p> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="1" data-aria-level="1"><span data-contrast="auto">Manage the day-to-day execution of outsourced bioanalytical activities for pharmacokinetic, immunogenicity, and/or biomarker assays conducted at CROs.</span><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"335557856":16777215}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="2" data-aria-level="1"><span data-contrast="auto">Provide scientific input to the design, development, qualification, validation, implementation, and maintenance of bioanalytical methods in accordance with applicable regulatory guidance and industry practices.</span><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"335557856":16777215}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="3" data-aria-level="1"><span data-contrast="auto">Review assay protocols, validation plans and reports, sample analysis plans and reports, and bioanalytical data packages for scientific quality, completeness, and data integrity.</span><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"335557856":16777215}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="4" data-aria-level="1"><span data-contrast="auto">Coordinate with CROs and internal partners to track milestones, communicate risks, and support timely availability of required scopes, quotes, contracts, purchase orders, samples, and reagents.</span><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"335557856":16777215}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="5" data-aria-level="1"><span data-contrast="auto">Plan and coordinate clinical sample analysis across multiple studies, including sample availability, testing priorities, laboratory timelines, and data delivery.</span><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"201341983":0,"335557856":16777215,"335559740":278}"> </span></li> </ul> <ul> <li data-leveltext="" data-font="Symbol" data-listid="4" data-list-defn-props="{"335552541":1,"335559685":720,"335559991":360,"469769226":"Symbol","469769242":[8226],"469777803":"left","469777804":"","469777815":"multilevel"}" data-aria-posinset="6" data-aria-level="1"><span data-contrast="auto">Work with internal and external subject matter experts to investigate and resolve issues that arise during assay development, validation, or clinical sample analysis.</span><span data-ccp-props="{"134233117":true,"134233118":true,"134245417":true,"201341983":0,"335557856":16777215,"335559740":278}"> </span></li> </ul> <ul