lilasciences · Cambridge, MA USA · Alewife, Cambridge, MA · One Charles Park, Cambridge, MA
<p><strong>Your Impact at LILA</strong></p> <div class="notion-selectable notion-text-block" data-block-id="5de37e11-bafd-4790-9ef7-c6f9465fdc04"> <div> <div> <div> <div class="x78zum5"> <div id=":r18m:" class="content-editable-leaf-rtl notranslate" data-content-editable-leaf="true">Lila Sciences’ Research Operations team executes the high-throughput laboratory workflows that power our scientific platform. We are seeking a motivated and detail-oriented Engineer I to support mammalian cell-based workflows, including electroporation, lipid nanoparticle (LNP) dosing, and chemical transfection. This is an on-site, first-shift role, with scheduled hours of either 7:00 AM to 3:00 PM or 9:00 AM to 5:00 PM based on operational needs.</div> <div> </div> </div> </div> </div> </div> </div> <div class="notion-selectable notion-text-block" data-block-id="3ec1a62c-8a83-8064-b4b7-effa2e86165f"> <div> <div> <div> <div class="x78zum5"> <div id=":r18n:" class="content-editable-leaf-rtl notranslate" data-content-editable-leaf="true">In this role, you will combine hands-on cell culture with laboratory automation to deliver consistent, high-quality materials for downstream applications. You will maintain mammalian cell cultures, operate automated liquid handlers and specialized instruments, monitor cell health and quality-control results, troubleshoot issues, and perform downstream characterization. You will partner with scientists and engineers to improve workflow reliability, scalability, and traceability.</div> </div> </div> </div> </div> </div> <p><strong>What You'll Be Building</strong></p> <ul> <li>Execute high-throughput automated and manual workflows, including electroporation, lipid nanoparticle (LNP) dosing, and chemical transfection.</li> <li>Maintain and passage mammalian cell lines and primary cells using aseptic technique, including cell counting and viability assessment.</li> <li>Prepare workflow materials and operate automated liquid handlers, electroporation instruments, and related laboratory equipment.</li> <li>Perform downstream characterization using flow cytometry, plate reader-based assays, or imaging-based methods.</li> <li>Monitor cell health, workflow performance, and quality-control results; troubleshoot issues and escalate as needed.</li> <li>Maintain traceable records, provide clear handoffs, and partner with scientists and engineers to improve standard operating procedures (SOPs) and workflows.</li> </ul> <p><strong>What You'll Need to Succeed</strong></p> <ul> <li>Bachelor’s degree in Biology, Biotechnology, Biochemistry, Cell Biology, Bioengineering, or a related scientific or engineering field, or an equivalent combination of education and relevant laboratory experience.</li> <li>Minimum 3 years of relevant Co-Op and industry laboratory experience.</li> <li>Hands-on mammalian cell culture experience, including aseptic technique, routine maintenance, passaging, cell counting, and viability assessment.</li> <li>Experience with mammalian cell transfection methods, including chemical transfection, electroporation, or related delivery technologies.</li> <li>Strong attention to detail and ability to follow SOPs and technical instructions while maintaining accurate, complete, and traceable documentation.</li> <li>Strong analytical and problem-solving skills, including recognizing deviations, performing initial troubleshooting, and escalating appropriately.</li> <li>Demonstrated ability to manage multiple priorities and execute reliably in a fast-paced, high-throughput laboratory environment.</li> <li>Strong communication and collaboration skills, with the ability to provide clear status updates and work effectively across teams.</li> <li>Ability to work on-site during first shift, with scheduled hours of either 7:00 AM to 3:00 PM or 9:00 AM to 5:00 PM based on operational needs.</li> </ul> <p><strong>Bonus Points For</strong></p> <ul> <li>Experience operating electroporation platforms, such as the Lonza Nucleofector or similar systems.</li> <li>Experience with LNP dosing or LNP-mediated delivery to mammalian cells.</li> <li>Experience handling primary human cells, such as peripheral blood mononuclear cells (PBMCs), T cells, or stem cells.</li> <li>Hands-on experience with flow cytometry, including sample preparation, instrument operation, or data analysis.</li> <li>Experience with plate reader-based or imaging-based cellular assays.</li> <li>Experience operating automated liquid handlers and associated software.</li> <li>Experience working in a high-throughput screening or production-oriented laboratory environment.</li> </ul><div class="content-pay-transparency"><div class="pay-input"><div class="description"><p><strong>Compensation</strong></p> <p>We offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact.</p> <p><strong>U.S. Benefits.</strong> Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program.</p> <p><stro