<h3><span style="font-size: 14pt;"><strong>tl;dr</strong></span></h3> <p><span style="font-size: 10pt;">General Proximity is a seed-stage startup developing the next generation of induced proximity medicines (IPMs). Our OmniTAC drug discovery engine furnishes molecules that co-opt existing cellular machinery to overcome therapeutic challenges, which have remained unapproachable to other modalities for decades.</span></p> <p><span style="font-size: 10pt;">We are seeking a <a href="https://www.youtube.com/watch?v=Uyzqmn8Azuo" target="_blank">first-rate</a> Lab Operations Manager to help us pioneer this uncharted frontier of drug discovery.</span></p> <hr> <h3><span style="font-size: 14pt;"><strong>Our Story</strong></span></h3> <p><span style="font-size: 10pt;">A long-standing challenge in drug discovery is the development of molecules capable of modulating difficult or "undruggable" targets. Disease-causing proteins can be dysfunctional in many different ways, but our armamentarium for fixing them is quite limited. The most common mechanism of action for FDA-approved drugs is inhibition<a href="https://www.nature.com/articles/nrd.2016.230" target="_blank">[1]</a>, but there are many other possible perturbation types whose potential remains unrealized.</span></p> <p><span style="font-size: 10pt;">General Proximity is a seed-stage drug discovery company developing a novel platform technology to solve this problem. We make bifunctional drugs that induce the modification of drug targets by existing cellular machinery (rather than through direct modulation by the drug, the classical approach).</span></p> <p><span style="font-size: 10pt;">Historically, the development of technologies that allow one to push new buttons in biology has been an incredibly fertile field for the discovery of new medicines[<a href="https://www.nature.com/articles/nrd3410" target="_blank">2</a>, <a href="https://www.nature.com/articles/nrd.2016.213" target="_blank">3</a>, <a href="https://www.nature.com/articles/nrd.2016.211" target="_blank">4</a>], and our technology holds the same promise.</span></p> <h3> </h3> <h3><span style="font-size: 14pt;"><strong>The Position</strong></span></h3> <p><span style="font-size: 10pt;">We are seeking an experienced Lab Operations Manager to support our Biology, Chemistry, and Platform teams. In this position, you will work at the intersection of lab management, operations, and biological research. <strong>This job requires strong skills and demonstrable experience in all three areas: lab management, operations, and cell/molecular biology</strong>.<br></span></p> <p><span style="font-size: 10pt;">Your responsibilities will include 1) general lab management: maintaining lab stocks, inventories and ordering, registering and preparing compound stocks, preparing buffers/media, and receiving supplies; 2) operations: procurement, vendor and service relationships, equipment acquisition and maintenance, and EHS compliance and lab safety; and 3) biological research: maintaining cell lines and performing cell-based assays alongside our scientists. You will also train new team members on our assays and lab systems, or coordinate that training.<br></span></p> <p><span style="font-size: 10pt;">This is a full-time, onsite role in San Francisco. <br></span></p> <h3> </h3> <h3><span style="font-size: 14pt;"><strong>About You</strong></span></h3> <p><span style="font-size: 10pt;"><strong>High Agency.</strong> Initiative, independence, and self-accountability are some of our most valued traits.</span></p> <p><span style="font-size: 10pt;"><strong>Systems-Minded.</strong> You build processes that keep running when you're not in the room and can scale with company growth.</span></p> <p><span style="font-size: 10pt;"><strong>Enthusiastic.</strong> We love people who are excited about what they are doing and are generally attempting to build a high-energy team.</span></p> <p><span style="font-size: 10pt;"><strong>Intensity and Grit.</strong> Early-stage startups are hard. Drug discovery is doubly so. We are looking for candidates who have a demonstrated ability to stick with complex problems for the long haul, with a team that has your back along the way.</span></p> <p><span style="font-size: 10pt;"><strong>Prosocial.</strong> We are here to create life-saving medicines for the patients who need it most. You should be, too.</span></p> <h3> </h3> <h3><span style="font-size: 14pt;"><strong>Qualifications & Nice-To-Haves</strong></span></h3> <ul> <li style="font-size: 10pt;"><span style="font-size: 10pt;">BS in Biology or related life sciences field, with a minimum of 2 years of experience maintaining laboratory operations, ideally supporting a group of 10+ scientists.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Excellent attention to detail, strong organizational and problem-solving skills, and clear written and interpersonal communication.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Track record of building lab systems and processes that run reliably and scale as the company grows.</span></li> <li style="font-size: 10pt;"><span style="font-size: 10pt;">Experience manag