<p><strong>ABOUT PIONEERING INTELLIGENCE </strong></p> <p>Pioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship’s integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond.</p> <div class="MuiGrid-root grid__StyledMuiGrid-fpUaVg itZaVt MuiGrid-item" data-birch="Grid"> <div class="MuiGrid-root grid__StyledMuiGrid-fpUaVg itZaVt sc-dUMaFF sc-dEWnit llOimw jcwIiU MuiGrid-container MuiGrid-spacing-xs-1 MuiGrid-align-items-xs-center" data-provides="stack" data-birch="Grid"> <div class="MuiGrid-root grid__StyledMuiGrid-fpUaVg itZaVt MuiGrid-item" data-birch="Grid"> <div class="MuiGrid-root grid__StyledMuiGrid-fpUaVg itZaVt MuiGrid-container MuiGrid-spacing-xs-1 MuiGrid-align-items-xs-baseline" data-provides="stack" data-birch="Grid"> <div class="MuiGrid-root grid__StyledMuiGrid-fpUaVg itZaVt MuiGrid-item" data-birch="Grid"> <p><strong><span data-contrast="none"><span data-ccp-parastyle="heading 2">The Role</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"335559738":160,"335559739":80}"> </span></strong></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">The Pioneering Intelligence group at Flagship Pioneering is building intel</span><span data-ccp-parastyle="Normal (Web)">ligent s</span><span data-ccp-parastyle="Normal (Web)">oftware systems that integrate agentic AI with scientific reasoning to accelerate discovery and decision-making. At the center of this effort is a new autonomous research platform. It supports autonomous AI systems that reason over complex biological problems.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">We are seeking a Principal Software Engineer to own the </span><span data-ccp-parastyle="Normal (Web)">underlying </span><span data-ccp-parastyle="Normal (Web)">agentic platform: the durable</span><span data-ccp-parastyle="Normal (Web)"> </span><span data-ccp-parastyle="Normal (Web)">orchestration layer on which long-running, multi-agent, multi-model scientific workflows run reliably.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">This is a hands-on architect role for a senior engineer who has built and operated distributed systems at scale and wants to t</span><span data-ccp-parastyle="Normal (Web)">ake age</span><span data-ccp-parastyle="Normal (Web)">ntic AI from research to production. You will set the technical foundation and standards for the platform, work shoulder-to-shoulder with AI scientists, engineers, and domain experts, and turn frontier agent patterns into reusable, dependable infrastructure.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <p><strong><span data-contrast="none"><span data-ccp-parastyle="heading 2">Key Responsibilities</span></span><span data-ccp-props="{"134245418":true,"134245529":true,"335559738":160,"335559739":80}"> </span></strong></p> <p><span data-contrast="auto"><span data-ccp-parastyle="Normal (Web)">Own the agentic platform end to end, from research prototype to production, building the durable orchestration layer for long-running, multi-stage scientific workflows. Architect </span><span data-ccp-parastyle="Normal (Web)">w</span><span data-ccp-parastyle="Normal (Web)">orkflow orchestration, evaluation frameworks, and event-driven distributed systems that deliver scale, resilience, and reliability.</span></span><span data-ccp-props="{"134233117":true,"134233118":true,"201341983":0,"335559740":240}"> </span></p> <ul> <li><span data-contrast="auto">Define SDK abstractions and API contracts between model and agent outputs and downstream consumers, decoupling rapid model iteration from product stability and reducing integration friction across teams.</span><span data-ccp-props="{}"> </span></li> <li><span data-contrast="auto">Deliver infrastructure-as-code reference implementations (AWS CDK, Terraform, containerized services) and transform exploratory AI proof-of-concepts into hardened, reusable patterns adopted across product domains.</span><span data-ccp-props="{}"> </span></li> <li><span data-contrast="auto">Own platform cost-efficiency and scalability while preserving the performance and accuracy that our experiments and end users require.</span><span data-ccp-props="{}"> </span></li> <li><span data-contrast="auto">Explore and template agent design and deployment patterns, and set technical standards, code quality, and architectural direction for the platform.</span><span data-ccp-props="{}"> </span></li> <li><span data-contrast="auto">Partner across teams (modeling and agent teams, product) to align on integration points, dependency