flagshippioneeringinc · Cambridge, MA USA · Cambridge, Massachusetts, United States
<p>What if you could join a rapidly growing company and play a critical role in bringing new medicines to patients by helping scale the programmable infrastructure behind a new human cellular biology platform?</p> <h3>About Vesalius</h3> <p>Vesalius Therapeutics is pioneering a new platform to generate breakthrough treatments for common diseases. Our platform combines large-scale human genetics, genomics, stem cell studies, high-dimensional cellular phenotyping, and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Vesalius was founded in 2019 by Flagship Pioneering.</p> <h3>Role Overview</h3> <p>Vesalius Therapeutics is pioneering a new platform to generate breakthrough treatments for common diseases. Our platform combines large-scale human genetics, genomics, stem cell studies, high-dimensional cellular phenotyping, and artificial intelligence to uncover causal biology and identify optimal intervention points for new therapies. Vesalius was founded in 2019 by Flagship Pioneering.</p> <h3>Key Responsibilities</h3> <ul> <li>Implement Benchling as a data platform, not only as an ELN: entity schemas, the Postgres warehouse, Insights, the API, and the supporting integrations.</li> <li>Establish sample tracking end to end. Chain of custody from donor material through line, vial, thaw, run and instrument output, and the links that let a result be attached back to the sample that produced it.</li> <li>Deliver analysis-ready data to the data team, including structured metadata capture, stable identifiers, and documented schemas with reliable handoff.</li> <li>Identify gaps in commercial software and design, ship and operate REST APIs and internal web applications, for example a results parser, a scheduling interface, or an app to integrate Benchling.</li> <li>Build integrations between automation platforms, instruments, LIMS/ELN, imaging systems, databases and downstream data pipelines.</li> <li>Build tools scientists use independently: search interfaces, pull lists, capacity dashboards.</li> <li>Investigate and resolve discrepancies, such as inventory that does not reconcile after a migration, and build the checks that catch them earlier.</li> <li>Apply sound software engineering practice: version control, testing, debugging, modular design, and documentation that someone else can maintain.</li> <li>Partner across scientific, automation, IT and data teams, bridging experimental work and the systems that record it.</li> <li>Anticipate future data and integration needs, plan for them, and stay flexible about learning new systems as the platform evolves.</li> </ul> <h3>Qualifications</h3> <ul> <li>Bachelor's or master's degree in computer science, engineering, bioengineering, biomedical engineering, computational biology or a related field, or a life science degree with a demonstrated programming record.</li> <li>4+ years building software, tooling or data infrastructure in a laboratory or R&D setting, including time as the person accountable for a system other people depended on daily.</li> <li>Strong Python and SQL: joins, aggregates, CTEs and window functions.</li> <li>Deep hands-on experience with a LIMS or ELN and its API. Benchling strongly preferred; Sapio, Dotmatics, LabVantage or similar all count.</li> <li>Experience shipping and operating a web application: a REST API, a front-end for other users, including authentication, deployment and maintenance.</li> <li>Experience with how data moves through a laboratory: how a sample is registered, how it becomes an experiment, how instrument output is captured, and how a result is attached back to the sample.</li> <li>Comfort with owning a domain independently, alongside strong scientific and hardware support.</li> <li>Strong communication and documentation skills, and the ability to work effectively across scientific, automation, IT and data teams.</li> </ul> <h3>Preferred Experience</h3> <ul> <li>Benchling: entity schemas, the warehouse, Insights, the developer platform, webhooks or apps.</li> <li>Parsing instrument output (plate readers, imagers, sequencers) into structured results tied to a sample.</li> <li>Cloud infrastructure such as AWS, event-driven integrations, or data pipelines supporting automated laboratory environments.</li> <li>Working alongside automated liquid handlers, integrated workcells or laboratory scheduling software (Hamilton, Tecan, HighRes Biosolutions, Dynamic Devices, Beckman or similar), as an integrator rather than a programmer.</li> <li>Mammalian cell culture at the bench, especially iPSC systems, and aseptic technique.</li> <li>Prior experience working in an automation-heavy laboratory environment.</li> <li>Ability to troubleshoot across software, hardware, instrument communication, data and sample-tracking workflows.</li> <li>Mentoring, or growing a small team.</li> <li>A regulated or GxP-adjacent environment or writing validation and verification documentation.</li> </ul> <p>At Flagship, we accept impossible missions to enable bigger leaps. Our <a href="https://www.flagshippioneering.com/values">core values</a> guide us through uncertainty and toward lasting impact.</p> <p><strong>We are an equal opportunity employer</strong>. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected b