<p><strong>The Role:</strong></p> <p>The Functional Bioassays team is seeking a Scientist II to develop, optimize, and execute functional assays across Generate’s therapeutic portfolio. This bench-focused role will generate high-quality data to guide protein design and program decisions, including AI/ML-enabled design cycles.</p> <p>The scientist will design, optimize, and troubleshoot biochemical and cell-based assays; execute high-throughput screening campaigns; analyze results; and support automation integration across programs. Work may include ion-channel, GPCR, ADC-related, and other functional assay platforms as portfolio needs evolve.</p> <p>Approximately 80–90% of this role will be laboratory-based. The scientist will collaborate with colleagues across Therapeutics, Technology, and cross-functional program teams to deliver well-controlled data for iterative design-build-test-learn cycles.</p> <p>This role is suited to a hands-on scientist with experience in functional assay development and high-throughput screening who can take ownership of experiments, communicate results clearly, and adapt to changing program needs.</p> <p><strong>Here's how you will contribute:</strong></p> <p>· Design, optimize, and implement high-throughput screening-compatible cell-based and biochemical assays, integrating automation where appropriate.</p> <p>· Plan and execute plate-based high-throughput screening campaigns, analyze results, and interpret experimental datasets.</p> <p>· Communicate findings to program teams to inform AI/ML-enabled design cycles, program decisions, and therapeutic optimization.</p> <p>· Support high-throughput functional assay work across multiple therapeutic programs, with potential focus areas including ion channels, GPCRs, and ADC-related assays.</p> <p>· Apply and expand expertise in novel functional assay technologies, including ion-channel and GPCR assays, as program needs evolve.</p> <p>· Conduct experiments with attention to detail, scientific rigor, and adherence to established protocols.</p> <p>· Troubleshoot assay performance, instrumentation, reagents, and workflows in partnership with senior scientists and Automation colleagues.</p> <p>· Maintain accurate, timely, and well-organized records in electronic laboratory notebooks and other data systems.</p> <p>· Prepare clear summaries of results for team discussions, program updates, and cross-functional meetings.</p> <p>· Coordinate experiments with colleagues across Functional Bioassays, Automation, Biology, Protein Sciences, Data Science, and program teams.</p> <p>· Follow laboratory safety practices, sample-handling requirements, data-integrity expectations, and Generate’s scientific standards.</p> <p><strong>The Ideal Candidate will have:</strong></p> <p>· PhD in cell biology, pharmacology, immunology, biochemistry, bioengineering, molecular biology, or a related discipline, with approximately 2+ years of industry or postdoctoral experience; or MS with approximately 5+ years of relevant industry or academic research experience; or BS with approximately 7+ years of relevant industry or academic research experience.</p> <p>· Hands-on experience with cell-based, biochemical, and functional assays in an academic, biotech, pharmaceutical, or related research setting.</p> <p>· Strong technical foundation in mammalian cell culture and plate-based assay workflows.</p> <p>· Experience with plate-based assay technologies such as ELISA, HTRF, AlphaLISA, luminescence or fluorescence assays, flow cytometry, or similar methods.</p> <p>· Experience designing, optimizing, and executing high-throughput screening in 384- or 1536-well formats for small molecules, biologics, or both, with appropriate controls and replicates, sound data quality, and clear documentation.</p> <p>· Ability to recognize assay-performance or data-quality issues, investigate likely causes, and contribute to troubleshooting.</p> <p>· Ability to work effectively in a fast-paced, matrixed research environment where priorities may shift across programs.</p> <p>· Strong organizational skills and the ability to manage multiple experiments or workstreams.</p> <p>· Ability to analyze and present data at scale using tools such as Spotfire, Dotmatics, ScreenWorks, Harmony, iQue Forecyt, or similar platforms.</p> <p>· Strong written and verbal communication skills, including the ability to summarize results, observations, and next steps clearly.</p> <p>· Collaborative working style, accountability, curiosity, and adaptability when learning new assay formats, therapeutic areas, and technologies.</p> <p><strong>Preferred Qualifications</strong></p> <p>· Experience with ion-channel assays or related functional readouts, such as patch clamp, membrane-potential, thallium-flux assays, or electrophysiology workflows.</p> <p>· Experience with GPCR assays, including reporter, calcium-flux, cAMP, IP-one, beta-arrestin, or other pathway-based functional assays.</p> <p>· Experience with ADC, image-based internalization, targeted protein degradation, immune-cell, or cytotoxicity assay formats.</p> <p>· Experience with organoid-based screening workflows.</p> <p>· Experience working with primary cells, engineered cell lines, or stable cell-line generation.</p> <p>· Experience with laboratory automation systems such as HighRes, Beckman Biomek i5/i7, Hamilton, EL406, Multidrop, or equivalent liquid-handling platforms.</p> <p>· Interest in applying functional biology to AI/ML-enabled therapeutic discover