<p><strong>POSITION SUMMARY: </strong></p> <p>Join Natera’s Oncology Research Use Only (RUO) team as a <strong>Supervisor</strong> for the Signatera Plasma Team. You will direct laboratory staff executing cell-free DNA (cfDNA) extraction, library preparation, and Next-Generation Sequencing (NGS) workflows to advance our personalized Minimal Residual Disease (MRD) assays. Every sample represents a real person, and you will ensure that all lab processes operate with the pace and precision required to support our clinical pipeline.</p> <p><strong>PRIMARY RESPONSIBILITIES: </strong></p> <ul> <li>Oversee the daily scheduling of employees executing DNA extractions, library preparation, Nucleic Acid Quality Control (QC), and NGS workflows</li> <li>Conduct regular 1:1 meetings to deliver unvarnished, data-backed performance evaluations and guide career development</li> <li>Take ownership of daily lab operations by directly executing sample processing alongside the team to maintain throughput</li> <li>Serve as the primary technical point of contact, using data to guide team members on data interpretation, next steps, and troubleshooting</li> <li>Execute process development and method/instrument testing to increase operational precision and scale</li> <li>Use data to identify lab process deviations, root-cause the underlying issues, and document findings via nonconformance reports to drive corrective action</li> <li>Draft, generate, and rigorously review Standard Operating Procedures (SOPs) and work instructions</li> <li>Maintain precise records of lab work using Google Sheets, Microsoft Excel, and internal Laboratory Information Management Systems (LIMS)</li> <li>Ensure accurate, ethical, and appropriate management of samples in strict compliance with all applicable federal regulations</li> <li>Think team by partnering directly with Oncology RUO peer groups to eliminate bottlenecks and optimize sample processing without needing translation layers</li> <li>Present data-backed summaries on team activities, project milestones, and timeline adherence</li> <li>Adapt to evolving science and operational needs, taking ownership of tasks that move the work forward without waiting for a finished playbook</li> <li>Handle protected health information (PHI) in paper and electronic formats as required to perform duties</li> <li>Complete required HIPAA/PHI privacy and security training within the first 30 days of hire and maintain current status on all training</li> </ul> <p><strong>QUALIFICATIONS: </strong></p> <ul> <li>BS/BA in a biological science or equivalent</li> <li>3 to 4 years of related laboratory experience</li> <li>Prior team management experience is highly preferred</li> <li>Must pass a post-offer criminal background check</li> </ul> <p><strong>KNOWLEDGE, SKILLS, AND ABILITIES: </strong></p> <ul> <li>Direct hands-on experience with nucleic acid techniques, including isolation, purification, quantification, amplification, and hybridization capture</li> <li>Extensive familiarity with rigorous pipetting practices using single- and multi-channel micropipettes and serological pipettes</li> <li>Hands-on experience operating Laboratory Automation platforms (e.g., Hamilton, Tecan, Biomek, QIAsymphony)</li> <li>Hands-on experience with library preparation and NGS platforms</li> <li>Proficiency with LIMS and database software</li> <li>Proficiency with Microsoft Office and Google Workspace applications</li> <li>Experience leading a lab team, spanning scheduling, training, workload prioritization, and building an execution-focused culture, is a plus</li> <li>Ability to think analytically, testing assumptions with data to troubleshoot and solve complex problems</li> <li>Clear, direct oral and written communication skills to present data and identify operational improvements</li> <li>Demonstrated interpersonal skills to build effective working relationships within the functional area</li> <li>Manage competing priorities while operating with pace and precision in an evolving scientific environment</li> </ul> <p><strong>PHYSICAL DEMANDS AND WORK ENVIRONMENT: </strong></p> <ul> <li>Duties are typically performed in an office and laboratory setting on a daily basis</li> <li>Requires the ability to perform repetitive motions during pipetting and sample processing</li> <li>Requires the ability to use a computer keyboard and read printed material</li> <li>Requires onsite work in San Carlos, CA, and flexibility to work shifted schedules (e.g., 7am–4pm, 11am–8pm, 7pm–3am) with a 30-minute break</li> <li>Weekend shifts may be scheduled based on operational demand</li> <li>May require lifting or moving items weighing up to 25 lbs</li> </ul><div class="content-pay-transparency"><div class="pay-input"><div class="description"><p></p> <p><strong><span style="color: #000000;">Compensation & Total Rewards </span></strong></p> <p><span style="color: #000000;">This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and skills considerations.</span></p> <p><span style="color: #000000;">This position is also eligible for additional compensation and benefits through Natera’s robust