Location: Oxford or London (Hybrid) The Mission: Why We Exist Genomics is a science-led transatlantic TechBio combining large-scale genetic and health data with proprietary analytics to accelerate drug discovery and advance predictive, preventative healthcare. We are united by a single vision to help people live longer healthier lives, using the power of genomics. Genomics aims to help people live longer, healthier lives in two ways: super-charging drug discovery and development for novel treatments with our AI-enabled advanced genetic analytics platform, and by helping people understand their personal risk of common chronic diseases through polygenic risk scores - giving doctors and health systems the chance to get the right people into the right prevention, screening and treatment programmes at the right time. Role Purpose Genomics runs on multi-trillion-row, petabyte-scale genetic and health data. Mystra is the analytical data platform that makes that usable, and MystraAI is the agentic layer we're building on top of it. This is a Staff-level role for someone who wants to push the boundaries of what a data platform can do — solving hard, novel infrastructure problems at genuine scale, and setting the technical direction that other teams build on. You'll lead the analytical data platform and our Data-as-a-Service offering, shape the data foundations behind MystraAI, and line-manage a small team of engineers while staying deeply hands-on. If you want your work to sit at the intersection of large-scale systems engineering and genuinely meaningful science, this is it. A Day in the Life The role spans the full depth of the platform — from database internals up to the systems that serve data across the product. On any given day you might be: • Pushing multi-tenant ClickHouse (or equivalent OLAP) clusters to their limits at multi-trillion-row, petabyte scale — designing sharding and replication strategies, building materialised views, and solving genuinely hard performance and cost/efficiency problems most engineers never get to touch. • Building the tooling and automation that lets data-intensive pipelines scale themselves — smart observability, predictive capacity planning, and systems resilient enough that incidents become rare rather than routine. • Shaping Data-as-a-Service as a real product — designing a secure, multi-tenant, immutable release architecture, with data made discoverable at scale through catalogue and ontology-driven search, in partnership with the data team. • Powering agentic AI from the data platform — architecting the data foundations behind MystraAI and designing secure, tenant-scoped access patterns for autonomous agents, partnering closely with the ML team on how our AI systems perform. • Treating security as a design problem, not a checklist — building tenant isolation, credential management and least-privilege access into the architecture from first principles. • Setting technical direction, mentoring engineers, and influencing decisions well beyond your own team. Who You Are You're a recognised specialist who leads through expertise — principal-level individual-contributor depth combined with the judgement to set standards others follow. You'll bring: • Large-scale OLAP / ClickHouse. Deep experience designing and pushing multi-tenant ClickHouse at extreme scale. You engage with the engine at source level rather than as a black box — and ideally have contributed code upstream. • Platform engineering at scale. You've built self-healing, observable systems for analytical data platforms and pipelines — the kind of engineering that reduces toil rather than manages it. • Data-as-a-Service productisation. You think in terms of data as a product: secure, multi-tenant, immutable releases, and discoverability at scale. • Agent-ready data. You understand what it takes to expose platform data to agents safely and at scale — access patterns, tenant isolation, sensible guardrails — and have scaled data infrastructure under demanding workloads. • Multi-tenant security. You design for isolation, least-privilege access and sound secrets management from the outset. • Technical leadership. You drive direction and innovation across a platform, mentor engineers, and can line-manage a small team without losing your own hands-on edge. Your Package We are committed to providing a transparent, supportive, and rewarding work environment. Compensation & Growth • Competitive Salary: Salaries are externally benchmarked annually to ensure top-of-market compensation. • Clear Career Path: A straightforward, open progression framework means you'll always know the path to promotion and how to achieve your next career goal. • Continuous Learning: Including external courses and a wide library of L&D materials, because your growth is our success. Wellbeing & Time Off • Holiday: 25 days annual leave, plus bank holidays, plus an extra 3-day company-wide shutdown at year-end. • Financial & Health Security: Robust benefits including a market-leading pension scheme, comprehensive private health insurance for you and your family with NO excess, critical illness, and life assurance. • Enhanced Leave: Enhanced paid family leave to support all new parents. Work Environment & Culture • Flexible Working: Hybrid Working (e.g., From our London, Oxford Office) • Truly Inclusive Time Off: Our 'Bank Your Bank Holiday' program allows you to exchange public holidays for dates that hold personal or cultural significance to you. • Vibrant Social Culture: From regular Town Halls and team picnics to organised sports events, our social committee ensures frequent opportunities to connect and celebrate. • Green Commute: Cycle-to-Work scheme and convenient office locations near major transport hubs. Ready to Build the Future? If this opportunity excites you, apply now! We are dedicated to creating a diverse environment and are proud to be an equal-opportunity employer. All qualified applicants will receive consideration for