<p><strong>Forge Your Future with Us:</strong></p> <p>At Forge Biologics, we believe in turning bold ideas into life-changing realities. Our mission is simple yet powerful: to enable access to life-changing gene therapies and help bring them from ideas into reality. We partner with scientists, physicians, biotech and pharma innovators, and patient communities — all united by one goal: improving lives. If you’re driven by purpose and excited to make a tangible impact, this is where your journey begins.</p> <p>Our team works out of The Hearth, a state-of-the-art, 200,000-square-foot cGMP facility in Columbus, Ohio. Here, you won’t just watch innovation happen — you’ll be part of it. Whether you’re scaling AAV manufacturing, collaborating on cutting-edge therapies, or supporting complex technical projects, you’ll play a key role in bringing hope to patients with genetic diseases.</p> <p>What sets Forge apart is our culture of <strong>H.O.P.E.</strong> We are <strong>hardworking</strong>, showing up each day with determination and grit. We are <strong>open</strong>, creating a space where ideas flow freely, and every voice is valued. We are <strong>purpose-driven</strong>, with every task directly tied to changing lives. And we are <strong>engaged</strong>, energized by the challenges we face and the milestones we achieve together.</p> <p>At Forge, your growth matters. We’re committed to helping you expand your skills, take on new challenges, and develop your career through mentorship, hands-on learning, and opportunities for advancement. Our people are our greatest investment, and we’re proud to see team members grow with us.</p> <p>If you’re ready to use your talent to help deliver hope to patients around the world, join us — and be part of something bigger than yourself.</p> <p><strong>About The Role: </strong></p> <p>As a Technician I, GMP Manufacturing - Downstream you will play a vital role in the production and purification of AAV-based gene therapy products in compliance with current Good Manufacturing Practices (cGMP) regulations. This position offers an exciting opportunity to contribute to the development and manufacturing of cutting-edge therapies that have the potential to transform the lives of patients.</p> <p><strong>Responsibilities:</strong></p> <ul> <li>Perform routine downstream manufacturing operations, including but not limited to chromatography, filtration, ultrafiltration/diafiltration, and viral vector formulation steps, according to Standard Operating Procedures (SOPs) and batch records.</li> <li>Prepare and operate equipment, such as chromatography systems, filtration systems, centrifuges, and tangential flow filtration (TFF) systems, ensuring they are properly calibrated and maintained.</li> <li>Execute purification processes for AAV-based gene therapy products, adhering to cGMP guidelines and maintaining a clean and organized work area.</li> <li>Monitor critical process parameters during manufacturing operations and report any deviations or abnormalities to the supervisor in a timely manner.</li> <li>Perform in-process testing and quality control checks, such as pH, conductivity, and pressure measurements, to ensure product quality and compliance with specifications.</li> <li>Assist in the execution of process validation and technology transfer activities, collaborating with cross-functional teams to ensure successful execution and timely completion.</li> <li>Follow safety procedures and adhere to environmental health and safety guidelines to maintain a safe working environment.</li> <li>Participate in training programs and stay updated with current industry trends, regulatory requirements, and advancements in gene therapy manufacturing processes.</li> </ul> <p><strong>Qualifications:</strong></p> <ul> <li>Bachelor’s Degree (B.A. or B.S.) in Biology, Biochemistry, Biomedical Engineering or related life science field (or equivalent experience).</li> <li>Strong technical aptitude, including demonstrated experience in applying scientific reasoning to solve complex problems.</li> <li>Excellent organizational skills and the ability to multitask in a fast-paced environment while adhering to strict timelines.</li> <li>Good interpersonal and communication skills, both written and verbal, to effectively collaborate with team members and stakeholders.</li> <li>Commitment to following SOPs, safety protocols, and regulatory guidelines to ensure compliance and product quality.</li> <li>Ability to adapt to changing priorities and work independently as well as part of a team.</li> <li>Flexibility to work in shifts, including weekends and holidays, as required by manufacturing schedules.</li> <li>Ability to stand for extended periods, and work in a cleanroom environment while wearing appropriate gowning and PPE. </li> </ul> <p><strong>Preferred Skills:</strong></p> <ul> <li>Prior experience working in a cGMP manufacturing environment.</li> <li>Downstream processing or biologics manufacturing experience.</li> <li>Familiarity with purification techniques and equipment commonly used in downstream bioprocessing, such as chromatography systems, filtration systems, and TFF systems.</li> <li>Basic understanding of viral vector-based gene therapy processes, principles, and quality requirements.</li> </ul> <p><em>This job description is not designed to cover or contain a comprehensive listing of activities, duties or r