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Principal Machine Learning Operations Engineer

definitivehc · Framingham, MA · Framingham, Massachusetts, United States · Remote, U.S.
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<div class="content-intro"><p><strong><span data-contrast="auto"><span data-ccp-parastyle="heading 1">About </span><span data-ccp-parastyle="heading 1">Definitive Healthcare</span><span data-ccp-parastyle="heading 1">:</span></span></strong><span data-ccp-props="{"134233117":false,"134233118":false,"134245418":true,"134245529":true,"201341983":0,"335551550":1,"335551620":1,"335559685":0,"335559737":0,"335559738":240,"335559739":0,"335559740":276}"> </span></p> <p><span data-contrast="auto">At Definitive Healthcare (NASDAQ: DH), we’re passionate about turning data, analytics, and expertise into meaningful intelligence that helps our customers achieve success and shape the future of healthcare. We empower them to uncover the right markets, opportunities, and people—paving the way for smarter decisions and greater impact.</span><span data-ccp-props="{"134233117":false,"134233118":false,"335551550":0,"335551620":0,"335559738":240,"335559739":240}"> </span></p> <p><span data-contrast="auto"><span data-teams="true">Headquartered just outside of Boston, Massachusetts, Definitive Healthcare operates across North America, Europe, and India, supporting a growing global client base of more than 2,400 customers since our founding in 2011.</span></span></p> <p><span data-contrast="auto">We’re also a great place to work. </span>In 2024 and 2025, we earned multiple workplace honors, including Built In’s 100 Best Places to Work in Boston (both years), a Stevie Bronze Award for Great Employers, and recognition as a Great Place to Work in India.</p> <p><span data-contrast="auto">We foster a collaborative, inclusive culture where diverse perspectives drive innovation. Through programs like DefinitiveCares and our employee-led affinity groups we strive to promote connection, education, and inclusion.</span><span data-ccp-props="{"134233117":false,"134233118":false,"335551550":0,"335551620":0,"335559738":240,"335559739":240}"> </span></p></div><p><strong>About the Role</strong></p> <p>We are seeking a hands-on Principal MLOps Engineer & Functional Lead to architect, build, and scale our next-generation Machine Learning and Generative AI infrastructure. In this role, you will design a unified, automated, and secure AI ecosystem capable of training and deploying both traditional predictive models and advanced Generative/Agentic AI systems at enterprise scale.</p> <p>As the Functional Lead, you will drive engineering excellence, establish MLOps best practices across the organization, mentor senior engineers, and translate strategic business objectives into robust, highly scalable automated pipelines.</p> <p><strong><span data-contrast="none"><span data-ccp-parastyle="heading 3">What </span><span data-ccp-parastyle="heading 3">You’ll</span><span data-ccp-parastyle="heading 3"> Do</span></span></strong><span data-ccp-props="{"134233117":false,"134233118":false,"134245418":true,"134245529":true,"201341983":0,"335559738":281,"335559739":281,"335559740":278}"> </span></p> <ul> <li>Design, implement, and maintain scalable, robust ML pipelines and data pipelines for CI/CD, and ML model deployments.</li> <li>Architect and govern the enterprise feature store and vector store infrastructure to support low-latency feature retrieval for both traditional ML and Retrieval Augmented Generation (RAG) applications.</li> <li>Build and manage enterprise-grade workflow orchestration layers to schedule, monitor, and manage complex, multi-stage model training and data processing dependencies.</li> <li>Be a subject matter expert for Generative AI infrastructure, building scalable frameworks to support advanced LLM applications, RAG pipelines, and multi-agent Agentic AI workflows.</li> <li>Establish highly efficient environments for model training and parameter-efficient fine-tuning of open-source and proprietary models.</li> <li>Optimize high-throughput, low-latency model inference pipelines, utilizing advanced caching and compute distribution techniques to handle large-scale concurrent requests.</li> <li>Establish and enforce lifecycle management policies utilizing an enterprise model registry to manage version control, lineage, and tracking from experimentation to production.</li> <li>Architect high-performing, cost-efficient infrastructure utilizing autoscaling groups on AWS to dynamically handle varying training and inference workloads.</li> <li>Implement comprehensive, real-time endpoint monitoring systems to track model performance, data drift, latency, and system health metrics.</li> <li>Serve as the functional lead for ML engineering, defining coding standards, architectural blueprints, framework selections, and operational SLAs.</li> <li>Provide technical guidance, code reviews, and mentorship to senior machine learning and data engineers, fostering an agile culture of innovation, automation, and continuous improvement.</li> </ul> <p> </p> <p><strong>What You'll Bring</strong></p> <ul> <li>Bachelor's or Master’s degree in Computer Science, Computer Engineering, Data Science, or a closely related quantitative engineering discipline.</li> <li>12+ years of professional experience in data engineering, ML engineering with a minimum of 5 years dedicated to building, scaling, and managing MLOps platforms in production.</li> <li>Deep, hands-on production experience architecting with in Databricks and native Aws environments.</

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