<div class="content-intro"><p><strong>About Us</strong><strong>…</strong></p> <p>Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our <span data-olk-copy-source="MessageBody">cytoDRiVE®</span> technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in clinical development for the treatment of patients with metastatic melanoma and <span data-olk-copy-source="MessageBody">non-small cell lung cancer.</span></p> <p>We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and Technical Operations team is based in our purpose built facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.</p></div><p><strong>Our Opportunity...</strong></p> <p><span data-contrast="auto">We are looking for an experienced and highly motivated scientist to help advance Obsidian's analytical sciences capabilities in support of late-stage clinical development, commercial readiness, and future BLA filings.</span><span data-ccp-props="{"335559739":160}"> </span></p> <p><span data-contrast="auto">The Scientist/Senior Scientist, Viral Vector Analytical Development is a key role within our Technical Operations group and will serve as both a technical leader and hands-on scientist, contributing to the development, optimization, troubleshooting, transfer, and lifecycle management of analytical methods for viral vectors for our first clinical stage autologous cell therapy program targeting solid tumors. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">You will partner closely with the Quality Control team and external testing laboratories to support method transfer and validation readiness while driving certain internal analytical development efforts. The successful candidate will work collaboratively across Analytical Development, Manufacturing, Process Development, Regulatory, Quality, and external partners to lead analytical development studies, apply statistical approaches to method development and comparability assessments, and provide technical expertise for assay transfer and lifecycle management. </span><span data-ccp-props="{"335559739":160}"> </span></p> <p><span data-contrast="none"> As a member of our Technical Operations team, </span><span data-contrast="none">you will be a vital part of a highly collaborative group working to unlock the promise of precision cell therapy for patients, starting with our lead program amsoki-cel (OBX-115), a novel engineered tumor-infiltrating lymphocyte (TIL) cell therapy that uses our proprietary cytoDRiVE® platform. This is a unique opportunity to be a valuable contributor in a well-funded clinical company with field-leading advisors, best-in-class partners, and an experienced team. </span><span data-contrast="auto"> </span><span data-ccp-props="{}"> </span></p> <p><strong><span data-contrast="none"><span data-ccp-charstyle="normaltextrun" data-ccp-charstyle-defn="{"ObjectId":"ac0262f4-8a9e-5820-b908-2d943c5f7113|1","ClassId":1073872969,"Properties":[201342446,"1",201342447,"5",201342448,"1",201342449,"1",469777841,"Calibri",469777842,"Arial",469777843,"Calibri",469777844,"Calibri",201341986,"1",469769226,"Calibri,Arial",268442635,"22",469775450,"normaltextrun",201340122,"1",134233614,"true",469778129,"normaltextrun",335572020,"1",469778324,"Default Paragraph Font"]}">This is a </span><span data-ccp-charstyle="normaltextrun">lab-based role</span> <span data-ccp-charstyle="normaltextrun">on-site in </span><span data-ccp-charstyle="normaltextrun">our Bedford, MA location</span><span data-ccp-charstyle="normaltextrun">, with flexibility for a hybrid schedule for certain activities outside of the lab</span><span data-ccp-charstyle="normaltextrun">.</span></span><span data-ccp-props="{}"> </span></strong></p> <p><strong>You Will...</strong></p> <p><em>Core responsibilities</em></p> <ul> <li><span data-contrast="auto">Lead the development, optimization, troubleshooting, transfer, and lifecycle management of analytical methods for retroviral vectors, ensuring methods are fit-for-purpose for late-stage clinical and future commercial manufacturing. </span><span data-ccp-props="{"335557856":16777215}"> </span></li> <li><span data-contrast="auto">Design and execute analytical development studies to evaluate method performance characteristics including accuracy, precision, linearity, range, robustness, comparability, and method capability using sound statistical approaches. </span><span data-ccp-props="{}"> </span></li> <li><span data-contrast="auto">Analyze and interpret complex datasets using JMP and other statistical tools to support assay development, comparability assessments, method characterization, and lifecycle management.</span><span data-ccp-props="{}"> </span></li> <li><span data-contrast="auto">Partner closely with Quality Control and external testing laborator