<div class="content-intro"><p><strong>About Us</strong><strong>…</strong></p> <p>Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our <span data-olk-copy-source="MessageBody">cytoDRiVE®</span> technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian’s lead program is currently in clinical development for the treatment of patients with metastatic melanoma and <span data-olk-copy-source="MessageBody">non-small cell lung cancer.</span></p> <p>We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and Technical Operations team is based in our purpose built facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.</p></div><p><strong>Our Opportunity...</strong></p> <p><span data-contrast="auto">We are seeking a highly motivated <strong>Senior Engineer, MSAT </strong>to support manufacturing of critical materials for our engineered autologous cell therapies. This role will serve as the technical bridge between development and external manufacturing for the retroviral vector and feeder cell process, responsible for ensuring that the processes run by CDMOs are sufficiently understood, controlled, reproducible, comparable, validated, and technically defensible for regulatory approval. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">This hire will oversee technology transfer, drive risk assessments, operating ranges, and control strategies. They will lead cross-functional efforts with Process Development, Analytical Development, Quality, External Manufacturing, and external CDMO partners to support manufacturing investigations and ensure readiness for PPQ and future commercial manufacturing.</span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="none"> As a member of our </span><span data-contrast="auto">Technical Operations Group, </span><span data-contrast="none">you will be a vital part of a highly collaborative group working to unlock the promise of precision cell therapy for patients, starting with our lead program amsoki-cel (OBX-115), a novel engineered tumor-infiltrating lymphocyte (TIL) cell therapy that uses our proprietary cytoDRiVE® platform. This is a unique opportunity to be a valuable contributor in a well-funded clinical company with field-leading advisors, best-in-class partners, and an experienced team. </span><span data-ccp-props="{}"> </span></p> <p><span data-contrast="auto">This is a Hybrid role based out of our Bedford, MA location, requiring travel up to 25–30% to support CDMO activities and occasional after-hours or weekend oversight of ongoing manufacturing runs as needed.</span><span data-ccp-props="{"201341983":0,"335559740":278}"> </span></p> <p><strong>You Will...</strong></p> <p><em>Core responsibilities</em></p> <ul> <li><span data-contrast="auto">Serve as a technical contributor and developing Subject Matter Expert (SME) for gamma-retroviral vector and feeder cell manufacturing activities supporting production of OBX-115, working closely with cross-functional teams.</span><span data-ccp-props="{"201341983":0,"335559740":278}"> </span></li> <li><span data-contrast="auto">Support and lead defined workstreams for technology transfer of manufacturing processes to CDMOs, including transfer of process knowledge, critical process parameters, control strategy elements, methods, and manufacturing documentation. Partner with Scientists or Engineers to ensure successful and reproducible execution at receiving sites.</span><span data-ccp-props="{"201341983":0,"335559740":278}"> </span></li> <li><span data-contrast="auto">Serve as Person-in-Plant (PIP), as needed, at CDMO facilities to support training, technology transfer, investigations, process monitoring, and execution of critical manufacturing activities. </span><span data-ccp-props="{"201341983":0,"335559740":278}"> </span></li> <li><span data-contrast="auto">Develop effective working relationships with CDMO technical and manufacturing teams.</span><span data-ccp-props="{"201341983":0,"335559740":278}"> </span></li> <li><span data-contrast="auto">Analyze manufacturing and process-monitoring data, identify trends and atypical observations, and work with the Principal /Senior Scientists or Engineers and cross-functional SMEs to establish scientific understanding and appropriate follow-up.</span><span data-ccp-props="{"201341983":0,"335559740":278}"> </span></li> <li><span data-contrast="auto">Support change controls, process improvements and validation activities by providing technical assessments and process knowledge.</span><span data-ccp-props="{"201341983":0,"335559740":278}"> </span></li> <li><span data-contrast="auto">Lead and support technical investigations, as appropriate, for deviations, process excursions, atypical results, and manufacturing failures in partnership with Manufacturing Process Development, Quality,